HKLM\System\CurrentControlSet\Control\SecurityProviders\Schannel\

value: CertificateMappingMethods
Data Type: DWORD
Data: 0x1F

If you are facing issues on a newly deployed NPS or even an existing one, whilst using a certificate method to authenticate your users/devices, you might find that the above registry key will resolve the issue.

There has also been reports about the below updates causing issues with NPS on Server 2019 –

KB5013641

KB5013941

KB5014754